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Submitted by: Justin DiMateo

Procedures to remove a mole are often fairly non-invasive and can usually be done in a doctor’s office using local anesthetic. Whether you are choosing to remove a mole for skin cancer suspicion, irritation or cosmetic reasons, there are a couple of methods that you can discuss with your doctor. The best procedure for you will depend on the size of the mole and the reason for removal.

Cosmetic Procedures

Skin mole removal that is done for cosmetic reasons is often completed by what is known as shave excision. This method will actually cut the mole away from the surface of the skin, leaving a smooth surface and minimal scarring underneath. This procedure begins with an injection of a local anesthetic that will numb the skin and raise the area slightly for easier removal. The mole is removed using a small, sharp scalpel that is sometimes lubricated with mineral oil for a smoother cut. No stitches are used and proper healing will result in a smooth surface and even contours.

There are some risks involved with the scraping excision procedure. Sometimes the procedure does not leave a smooth contour, which may result in the need for additional cosmetic treatment to finish off the process. In other cases, melanocytes are left below the surface of the skin to cause mole re-growth. In these cases, a second procedure is often required, and is usually done by a different method.

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Getting Rid of Irritation

There are other situations that warrant a skin mole removal because the mole is located in an area that receives frequent irritation from clothing rubbing against it. Another problem might be that the mole is within the shaving area, making it difficult to complete this daily task. In these situations, the method of choice may vary between scrape excision and what is known as elliptical excision. With this process, an area of skin is cut out around the mole, and then sewn together once again. A successful procedure will allow for a smooth rejoining without puckering at the site of the incision. However, this procedure carries with it a higher risk of bleeding or infection.

Skin Cancer Screening and Treatment

When skin cancer is suspected, skin mole removal becomes more critical to ensure that all of the cancer cells are removed along with the mole. Because of this, it is most common to have an elliptical excision take place that allows the doctor to remove cells surrounding the mole so that they can also be tested. If a biopsy is done using the scraping method and the cells are found to be malignant, an elliptical excision is usually the next step.

No matter what type of skin mole removal you and your doctor decide upon, the success of your procedure will greatly depend upon the skill and experience level of the doctor. While some general practitioners will perform basic mole removal, a dermatologist is often the specialist of choice for more involved procedures, such as skin cancer treatment. The right doctor will make all the difference in successful mole removal.

About the Author: For more information on the procedures or treatment visit Dr. Navarro’s clinic for

Mole Removal

or for questions on

Skin Mole Removal

in Palm Beach, Florida.

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Friday, September 1, 2006

Results of gene therapy trials at the US National Cancer Institute, Bethesda to fight cancer published online yesterday by the scientific journal Science show some levels of success. However experts have warned that despite the promise more work is needed for this to become a viable cure.

Dr Stephen Rosenberg, who lead the research team, said “It’s important to emphasize this is a highly experimental treatment that’s still in the course of development.”

The team treated 17 terminal skin cancer patients with modified cells from their immune systems. The technique uses genetically modified white blood cells (more specifically T cells) to attack and kill the cancer cells. Of the 17 subjects only 2 were cured of the disease (an aggressive form of skin cancer called a melanoma which is usually fatal in advanced stages). Before the treatment, which lasted 18 months, the patients were only expected to live for up to 6 months. The remaining 15 patients were not affected by the treatment.

One of the successful patients was Mark Origer (53) from Wisconsin. He has been fighting cancer since first being diagnosed in 1999. After finding out about the new trial on the internet he applied and, after interviews, was accepted along with 16 other candidates. The treatment removed Origer’s melanoma and also shrunk another tumor in his liver – to the extent it could be removed surgically. Doctors confirmed he was free of the disease last week, nearly 2 years after treatment began. A second man (39) was cleared of his cancer which had spread to the lungs, liver and lymph nodes. Cancer that progresses to the lymph nodes is usually untreatable and fatal.

T cells can attack and destroy bacteria and other harmful cells like cancer cells. However cancer cells sometimes reduce the signals on their outer surface by which they are recognised, so the immune system cannot affect them. Gene therapy involves modifying some of a patients T cells to contain a new receptor. (Receptors are what enable the immune cell to identify harmful cells, like those corrupted by viruses. The new receptor is inserted with the use of a viral vector, i.e. a virus made safe to insert the receptor in the cell.

In the trial, T Cells were removed from each patient and modified in the laboratory. Patients underwent chemotherapy to kill most of their current immune system, which was replaced by the mutated cells. The modified cells successfully survived after injection into the body – making up 10% of the subject’s T cell count during the first 2 months. The team is now looking for ways to enable the cells to survive longer and in greater numbers.

Experts have called this a significant technical advance but warn that more patients need testing and the technique refining before any conclusive results can be drawn. Dr Edel O’Toole, consultant dermatologist and British Skin Foundation spokesman, said: “I think that the success of this approach in two patients shows promise, however 15 patients did not respond to the treatment suggesting that further work is needed to optimise this approach for all patients, which could take many years.”

Rosenberg now hopes to run a new trial with possibly stronger gene therapy treatments, he is currently awaiting FDA approval.

Gene therapy was much hyped after it’s first successful application in so called “bubble boys” (patients with severe combined immunodeficiency). After follow-up, these trials were stopped when it was discovered that three of eleven patients in one trial had developed leukemia.



Monday, August 7, 2006

Dogs can be trained to detect early and late stages of lung and breast cancer accurately according to a study published by California scientists in the little-known scientific journal Integrative Cancer Therapies.

The study took place over the last five years at the Pine Street Foundation, a non-profit organization which conducts evidence-based research on integrative medicine (combining complementary and alternative medicine and mainstream medicine). Michael McCulloch and colleagues used three Labrador Retrievers and two Portuguese Water Dogs, both common pets, that received basic behavioral dog training. The researchers trained the dogs to lie down next to a sample from a cancer patient and to ignore other samples.

The samples used were breath samples from 55 patients with lung cancer and 31 with breast cancer — the two types of cancer with the highest mortality rates in the United States.

After the training phase, the dogs’ accuracy diagnosis was tested in a double-blind experiment. Among lung cancer patients, the sensitivity and specificity were 99% accurate and for breast cancer sensitivity was 88% and specificity 98%. Because these figures seem almost too good to be true, cancer experts are the same time baffled and skeptical. The authors of the study themselves also say replication of the study is needed.

Importantly, this was independent of the cancer stage, meaning the dogs were able to pick up the scent of cancer in its early stages. This is important because in many cases, the success of any treatment depends on early diagnosis. However, the researchers don’t believe this will lead to the use of dogs in the clinic soon, rather they want to find out which chemicals are actually sensed by the canines, because they could be used in laboratory assays. “It’s not like someone would start chemotherapy based on a dog test,” Dr. Gansler of the American Cancer Society said, “They’d still get a biopsy.”.

The researchers were inspired by anecdotal reports about dogs detecting cancer. In 1989, a British women consulted with her family physician because her Dalmatian kept licking a mole on her leg. At biopsy it showed to be malignant melanoma. When diagnosed too late this form of cancer has a poor survival rate, but in this case early surgery was made possible, and the women survived. Prior studies showed that breath samples from patients with lung cancer or breast cancer contain distinct biochemical markers. This provides a basis for the hypothesis that some cancer types produce volatile chemicals that dogs could smell. A study published in the British Medical Journal already proved that dogs could use their exquisite sense of smell to detect bladder cancer in urine samples, but they were only correct in 41% of cases, and another study provided preliminary evidence that dogs could detect melanomas.

This doesn’t mean you can show your breasts to your dog and it will tell you if you have cancer, other physicians caution, and scientists do not advise people to train their dogs to sniff for cancer. Unresolved issues from the study include the fact that subjects were required to breathe deeper than normal, so it’s not sure whether dogs can smell cancer in normal breath. Also, whether this is a permanent skill that would be retained by dogs was not tested.

Finally, there are concerns that could arise over liability issues: who would be responsible when the dog makes a mistake?

Current detection methods for both lung and breast cancer are not flawless. For lung cancer, chest X-ray and sputum cytology (detecting cancer cells in coughed up fluid) fail to detect many early cases, and CT scan produces many false-positive results unless combined with expensive PET scans. Although it might be comparing apples and oranges, a $2.5 million CT scanner has an accuracy of 85 to 90%. Mammography also produces false-positive results, and it may be difficult in women with dense breast tissue. As such, another type of “pet”-scan, using dogs as a biological assay, might prove feasible for screening if supported by further research. Current tests are also expensive so the use of dogs for preliminary cancer testing could prove to be an affordable alternative for countries in the developing world.



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Submitted by: Seomul Evans

One of the oldest towns in Sardinia and also it’s second largest; Sassari is perfect for those tourists who wish to experience both, the modern as well as ancient Sardinia.

Old & New in Sassari

Sassari was founded in the early Middle Ages. Tathari, as it was called many centuries ago, was first mentioned in 1113 an archived document from the Monastery of St. Peter. In 1274, the Republic of Pisa gave Sarassi semi-independent status. Twenty years later, it become on the only free commune in Sardinia and allied with Genoa. Happy to be free from the rule of Pisans, it created statutes in 1316 that were very lenient when they were compared to the normal rules of the Middle Ages.

From then on, Sardinia and Sassari had many centuries of war, domination, plagues, and crisis. Finally, after 1861, Sassari became part of the Kingdom of Italy.

During this period of unrest however, there were also times of economic prosperity. The Sardinian University was founded in 1562. The university is the oldest one found in Sardinia and it has built an exceptional reputation for itself. The libraries house many ancient documents, including the Condaghes, which were the legal codes first used by Sardinia. It also has the first known documents that were written in the native Sardinian language.

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If you are traveling to Sardinia as a tourist, you certainly must take time to visit Sassari. There are several sites worth visiting and you can find accommodations for every budget. There are hotels, holiday houses, and villas that can provide you with the perfect vacation.

Some of the more popular tourist attractions in Sassari include:

1. Monte Daccoddi: This archeological site is a unique monument from prehistoric times and is definitely something worth seeing.

2. The Pisan City Walls: These walls were from the 13th century and once consisted of 36 towers. Now only 6 remain. In 1877, the Aragonese Castle was destroyed, but the ruins were rediscovered during 2008.

3. The 12th century church of St. Peter, which was renovated during the 17th century. This was where the original code documents were found.

4. Corso Vittorio Emanuele: the main street in Sassari, which features numerous shops, restaurants, and hotels.

5. The Ducal Castle: This castle was built in the 18th century for the Duke of Asinara. It now houses the Town hall.

6. The Fountain of the Rosello: This fountain was built in 1606 and is a centerpiece in the town. The two Genoese craftsmen created the fountain by using two squared parts, and then using two crossed arches so the Statute of Sat. Gavins could be placed on top of it.

There are also a number of museums in Sassari. These include the Museum of Science and technology, the National Archaeological Museum, The National Pinacotheca, and a contemporary art museum.

Another great aspect of Sassari is the how easily accessible the rest of the island is. You can quickly get from one major city or town to the next. You do need to heed the speed limits, however. There are many secondary roads that are winding and narrow. It can be difficult to tell if another vehicle is coming.

As a tourist, Sassari is simply a wonderful town to visit and stay for a few days. Wonderful hotels, terrific restaurants, and a wide array of activities help to make Sassari one Europe’s primary vacation destinations. If you plan to visit frequently, you may want to consider purchasing one of the villas or holiday houses. There are surely many to choose from. You cannot go wrong if you decide to visit Sassari, Sardinia on your next family vacation.

About the Author: Seomul Evans is a senior

Internet Marketing

consultant,

Blogger

and copywriter with leading

Sardinia Hotels

Sardinia booking services provider.

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Friday, August 30, 2013

Workers including drivers for Kuehne and Nagel Drinks Logistics (KNDL) have voted in favour of striking. KNDL, which delivers beer and soft drinks to about 30,000 locations in the UK, was in talks with Unite yesterday to try and resolve the dispute.

The vote is a response to a proposed restructuring in which a number of operations currently performed at the firm’s 29 distribution centres would be relocated to three new ‘super-hubs’. Although no distribution centre closures are currently planned, the union says workers fear future job losses, and are also concerned products will spend more time on the road, spoiling the taste of beer.

A Unite official said “We have tried to engage with the company but they have repeatedly failed to resolve this dispute.” A KDNL spokeswoman said “We are committed to continuing dialogue with Unite in order to reach a resolution before any action is taken.” She also pointed out Unite is yet to decide dates for the strike; Unite has described “one final chance” to resolve the dispute.

A Unite ballot of 970 KNDL employees produced a turnout of 64% of which 85% voted to strike. The distribution centres involved are mostly in England, but sites in Aberdeen, Dundee, Bathgate, and Inverness in Scotland and Swansea in Wales are also affected.

KNDL delivers high-profile brands including Britvic soft drinks and Heineken, Kronenbourg, and Fosters beer. Customers include chains Weatherspoons, Enterprise Inns, and Trust Inns, and airports, cinemas, and leisure centres. Even Premier League football clubs are among KNDL’s delivery rounds.



Sunday, October 11, 2009

Boyzone member Stephen Gately has died suddenly at the age of 33 while on holiday on the Spanish island of Majorca.

Gately was on holiday with his partner Andrew Cowles when his body was found on Saturday. The information was confirmed on Boyzone’s official website on Sunday. The other members of Boyzone were said to be travelling to the same island on Sunday before his death was discovered. Dan Wootton, showbusiness editor for British tabloid News of the World, told BBC News that the singer had left the means of accommodation to go out for some drinks, returned, fell asleep and never woke up again. Spanish police report his body was found on a sofa in the lounge.

Louis Walsh, manager of the group and also a judge on UK television singing competition The X Factor, commented, “We’re all absolutely devastated. I’m in complete shock. I was only with him on Monday at an awards ceremony. We don’t know much about what’s happened yet. I only heard after The X Factor and we will rally around each other this week. He was a great man.”

A spokesperson for Spanish police said today in Majorca, “[a]t the moment it is not known how he died. There are no signs of suspicious circumstances. “Gately’s time of death was given as approximately 13.45 UTC. The police spokesperson added, “[d]etails remain pretty unclear. We managed to take a look at some documents, they tell us that police received the body around half past four. We think we know he was drinking in a bar, perhaps they went to a restaurant, but none of this is confirmed.”

Gately’s family hope to hold his funeral in Dublin, Gately’s home town. A representative of the family stated they are “shattered”.



Saturday, April 12, 2008

On the back of new restrictions being imposed on eBay users in the United Kingdom requiring that sellers offer PayPal payments for all sales, eBay Australia is mandating that only PayPal payments will be acceptable as of June 17. PayPal is a wholly-owned subsidiary of eBay, and charges a 30¢ transaction fee, plus a commission between 1.1% for high volume traders, and 2.4% for low value or low volume traders. These higher costs will be passed onto buyers.

Cash payment on pick up will be the only other payment option, and it may only be offered in conjunction with PayPal.

eBay has brought in this restriction under the guise of improving customer protection, bolstering its “Paypal Buyer Protection” insurance programme to allow claims up to A$20,000 instead of the previous maximum of $3,000, however as of June 17 many of the items which would exceed $3,000 are no longer covered by the programme, such as services, vehicles, real estate and businesses.

eBay Trust and Safety director Alastair MacGibbon said this change was not in response to the once-off fund established in March to refund eBay buyers who lost their non-existent holiday accommodation packages from the Melbourne eBay seller Robert Kobis. Mr MacGibbon said “It is part of a much larger initiative”.

In addition to these measures, Paypal will be withholding funds from some sellers for 21 days

.. until the earliest of the following occurs:

  • the buyer leaves positive feedback,
  • 3 days after confirmed item delivery
  • 21 days without a dispute, claim, chargeback, or reversal filed on that transaction

The Australian Competition and Consumer Commission has held discussion with eBay, but declined to comment. The Australian Consumers Association spokesman Christopher Zinn said the unique use of PayPal could give rise to competition issues, however if the costs charged stayed as they were, they had no further concerns.



Advertising Is An Art

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Advertising is the way that you get your product known by the masses of the world. We all have seen advertisements for such things as the PC, or Apple, or any kind of cell phone, they are all over the television. However, this is not the only way you can go about advertising.

You have newspapers that you can advertise in, which may not reach as many as the television ads, but it’s quite a bit cheaper. How about a home-made flyer that you can either print up or computer generates, the way it looks more professional is the best way to go about making an advertisement this way.

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There are those weekly flyers that come out in about every city that you can put a short little add into, and it’s not really a bunch of money to advertise this way either. You can even write up little index cards and take them into laundry mats and advertise a service or product.

You might want to put up flyers around the neighborhood, or put them on the mailbox of some houses, like if you are advertising your new lawn mowing service. It may help you never know who might call you. When you go to advertise never underestimate the simple ways to advertise.

Even walking into a store and just telling the people behind the counter of your new business your starting up is a great way to advertise, you never know they might need what you are selling, or know someone who does.

Advertising is a way to make people notice you, and with all the ways that you can go about it you should be able to at least receive one or two phone calls. Heck even if you have to situate yourself in front of a store and hand out flyers to the people who are coming out of the store, you just need to make sure that you are always polite, no matter how nasty they get with you.

Or advertise online on your own website, or even post them into blogs that you post on several websites. With one of these ways to advertise you should be able to pick up a few phone calls and possible customers for your new business. In fact you might even get the best advertising the free word of mouth that passes from someone who has used your services and tells their friends all about you.

Check out Karl Sultana’s

search engine optimization tools

. The seo strategies you discover can help you get high rankings for practically any keyword you desire.

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Thursday, March 9, 2006

Bars and nightclubs in London, Manchester, and Newcastle, UK, now carry vending machines selling sex toys for about £5. These fuchsia-pink Tabooboo machines are usually located near toilets to render deliberating customers a modicum of privacy. However, some hairdressing salons are giving the machines “center stage”. Products available from these unconventional vending machines include mini vibrators, “silicone ticklers”, “lust fingers”, and bottles of “love liquid” (an edible lubricant).

The Alphabet Bar in London’s West End, host to the first sex toy vending machine in the U.K., claims many people visit especially for the machine, and describes it as a “great success”. Alan Lucas, the managing director of the company behind this enterprise, Tabooboo, suggests that the success of the machines is due to younger people having a more liberal view of sex toys. He stated, “The most popular product is a vibrating rod ring which is something [the man] wears [on his penis]”.

The machines are expected to begin appearing in the U.S. and Italy.



Thursday, December 22, 2011

The Italian senate has approved in a 257 to 41 vote a €30 billion (US$39 billion or £25 billion) austerity package that Italian prime minister Mario Monti has called the “Save Italy Decree”. The measures had previously passed in the Chamber of Deputies, Italy’s lower house, with a 402 to 75 vote.

The economic changes include raising the retirement and state pension age, the reintroduction of a local housing tax, spending cuts on health, and a ban on cash transactions over €1,000 (US$1,300 or £830) to prevent tax evasion.

Monti told the Senate before the vote: “Our country’s credibility is essential to overcome the crisis, just as it’s also essential for our economy to return to growth”. The economic reforms have been supported by the People of Freedom, the political party of former prime minister Silvio Berlusconi.

However, Umberto Bossi from the Lega Nord party attacked the plans, claiming “[i]t’s got too many taxes and above all, it doesn’t create jobs.” Trade unions are also expected to oppose the changes.



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